Pele’s Match Against Colon Cancer: How Colon Cancer Caused Multi-Organ Failure In Pele

Medically reviewed by: Eiman Firoozmand, MD
Last modified on January 2nd, 2023

The world is in shock and mourning the loss of a legendary athlete. Edson Arantes do Nascimento, more commonly known as Pele, recently passed away due to complications of colon cancer.

Pele was a Brazilian soccer icon and three-time World Cup winner, playing in five World Cups and setting multiple records. He was an inspiration to generations of soccer fans around the world. 

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The fact that colon cancer took him away in just over a year highlights how dangerous, and aggressive the disease can be.

In this post, we’ll discuss how colon cancer caused multi-organ failure in Pele and how it can be prevented. We hope Pele’s story (and that of Chadwick Boseman’s battle with colon cancer) will serve as a reminder to everyone that timely diagnosis and treatment are key when it comes to fighting cancer.

What disease did Pele have?

Pele had colon cancer, which was removed via surgery in September 2021. In particular, the great footballer had right-sided colon cancer, which has slightly different symptoms from left-sided colon cancer.

Diagram of the left & right of the colon

The left side of the colon has a smaller diameter than the right side. This means when left-sided colon cancer develops, patients experience a narrowing of the stool and changes in the frequency and consistency of bowel movements.

On the other hand, right-sided colon cancer often causes iron-deficiency anemia and black-colored stools due to bleeding. 

But it does not affect bowel movements in the same way as left-sided colon cancer. That’s because the right side of the colon is much wider and does not become as easily blocked due to a tumor.

In fact, right-sided colon cancer can be asymptomatic for a long time, meaning it does not show any signs or symptoms until it is advanced. This can make it difficult to diagnose early, so Pele’s cancer was probably detected at an advanced stage.

What are the stages of colon cancer?

There are 5 main stages of colon cancer, and it’s important to know how cancer causes multi-organ failure in Pele.

Here is how colon cancer is staged:

  • Stage 0: The cancer is limited to the colon’s lining, has not invaded the wall, and has not spread to other organs.
  • Stage I: The tumor is still small and only involves the first two layers of the wall, and hasn’t spread beyond the colon.
  • Stage II: The tumor has grown and involves three to four wall layers but has not invaded distant organs.
  • Stage III: Cancer involves any number of layers AND has spread to surrounding Awww wlymph nodes, but has not involved any distant organs yet.
  • Stage IV: Cancer has spread to distant organs, such as the liver, lungs, and brain.

Importantly, the survival rate for colon cancer patients is directly linked to the stage at which it is diagnosed. 

For example, 90% of patients with localized disease survive for 5 years after diagnosis. On the other hand, only 14% with stage IV colon cancer are alive at 5 years after cancer detection.

So the earlier this cancer is caught, the better the chances for successful treatment and survival.

How did colon cancer lead to multi-organ failure in Pele?

There are two possible ways colon cancer could have caused multi-organ failure in Pele. One is the direct involvement of distant organs, such as in stage IV colon cancer. And the other is the side effects of the drugs used to treat the condition.

Direct involvement of distant organs

When colon cancer becomes advanced, it usually spreads to the liver first. When this happens, the liver cannot effectively break down and remove toxins from the body. This can lead to a wide range of complications affecting multiple organs, such as:

  • Coagulation problems, where patients become more likely to bleed
  • Hepatorenal syndrome, where the kidneys begin to fail due to liver damage
  • Hepatopulmonary syndrome, which is lung dysfunction as a result of liver failure
  • Hepatic encephalopathy, where toxins from the liver enter the brain and cause confusion
  • Esophageal varices, which are dilated veins near the stomach that can cause life-threatening bleeding

Keep in mind that these are complications of colon cancer as a result of liver involvement. Colon cancer can also spread to other organs, such as the lungs and brain. This would obviously lead to further organ failure problems.

Treatment-related complications

In 2021, Pele had surgery to remove his colon cancer. Following that, he was started on chemotherapy, which is a combination of drugs that kills any remaining cancer cells but can also cause side effects.

Chemotherapy drugs used to treat colon cancer usually include:

  • Cetuximab, which can lead to acne
  • Oxaliplatin, which can damage the kidneys, nerves, and hearing
  • 5-fluorouracil, which can cause heart damage, liver dysfunction, and confusion
  • Bevacizumab, which can lead to high blood pressure, stroke, and abnormal blood clots
  • Irinotecan, which can slow down the production of white blood cells, increasing the risk of infections

As you can see, all of these drugs can cause serious side effects that lead to multi-organ failure.

In the case of Pele, a combination of direct organ involvement and treatment-related side effects likely caused the multi-organ failure.

Keep in mind that not every patient who takes these drugs will experience serious side effects. In fact, doctors monitor patients undergoing chemotherapy very closely to ensure any side effects are caught early and treated promptly.  Without treatment, cancer can spread further and decrease the chance of survival. Also, not every patient with colon cancer will need chemotherapy.

It’s also important to note that not all patients with colon cancer will experience multi-organ failure. If detected early, the chances of successful treatment and survival are much higher. This is why it’s so important to detect colon cancer in its early stages.

How to detect colon cancer in its early stages?

Determining your risk of colon cancer and undergoing an appropriate screening test is key to detecting the condition early.

There are two risk categories for colon cancer — average risk (which includes the general population) and high-risk patients.

People with an average risk of colon cancer are those with the following:

  • No family history of colon cancer, which can indicate colon cancer being in your genes
  • No history of inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn’s disease
  • No history of cancerous polyps, which are abnormal tissue growths in the colon

In these people, experts recommend screening for colon cancer through a complete colonoscopy every 5 – 10 years once a person crosses 45 years of age. 

This should be continued until 75 years of age, after which it can be discontinued depending on the overall health of the patient.

Diagram of what occurs during a colonoscopy

Source

On the other hand, high-risk patients with established risk factors for colon cancer — such as those with a family history of colon cancer or IBD — should start screening at an earlier age and undergo a colonoscopy more frequently.

Early detection is key to treating colon cancer

Remember, colon cancer is a treatable condition in its early stages. Identifying your risk status, taking adequate preventive measures, being aware of the signs and symptoms, and undergoing regular screenings are all key to catching the condition early.

If you or someone you know has symptoms of colon cancer, speak to a healthcare provider as soon as possible. 

If you still have any questions or concerns, don’t hesitate to contact us for further advice. We’re here to help.

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